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KMID : 0043319920150010087
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Archives of Pharmacal Research
1992 Volume.15 No. 1 p.87 ~ p.90
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Synthesis of Substituted Pyridine-2,4-dione Nucleosides
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Lee JK
Won JH/Park JS/Hwang CH/Chung KH/Ryu EK
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Abstract
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The syntheses of novel heterocyclic base modified pyrimidine nucleosides are described. 5,6-Dimethyl4-hydroxy-3-methoxy-l-(beta-D-ribofuranosyl)-2(1H)-pyridinone 7 was synthesized by condensation of silylated 5,6-dimethy]4-hydroxy-3-methoxy-2(1H)-pyfidinone with beta-D-ribofuranose-l-acetate-2,3,5-tribenzoate in dichloroethane in the presence of Lewis acid followed by debenzoylation. The 2,2’’-anhydro-5,6-dimethyl-2-hydroxy-3-methoxy-l-beta-D-arabinofuranosyl-4-pyridinone 8 was obtained from the reaction of the free ribonucleoside 7 and diphenyl carbonate in DMF. None of these compounds showed any significant antiviral and antitumor activities in vitro tests.
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